House dust mite sensitization and frequent antibiotic courses may suppress remission of rhinosinusitis and asthma symptoms in young children
| Autorzy publikacji z podkreśleniem autorów z projektu BBMRI.pl | Molińska K., Latek M., Rychlik B., Lach J., Strapagiel D., Majak J., Błażowski Ł., Jerzyńska J., Kuna P., Majak P. |
| Nazwa czasopisma | Allergy |
| Rok publikacji | 2021 |
| IF czasopisma w czasie publikacji pracy | 13,146 |
| Punkty MNiSW w czasie publikacji pracy | 140 |
| Streszczenie w j. angielskim lub krótki opis pracy | Our data suggest that contact with peers determines the natural history of CRS and asthma in young children. Importantly, we described the group of children at risk of persistent symptoms despite isolation from peers. Children with HDM sensitization and more frequent antibiotic courses are at risk of moderate CRS and, consequently, the persistence of asthma symptoms. Atopic sensitization and frequent infections are the epiphenomena of CRS in young children. In this study, we pointed out the possible link between these inflammatory pathways. HDM-sensitized children had the feature of upper-airways dysbiosis at baseline and antibiotic courses more frequent during pandemic social isolation. Our results suggest that both aspects: atopy, especially sensitization to HDM and frequent infections, should be included in the clinical approach to CRS/asthma in young children. However, further research is required for functional studies to elucidate the molecular mechanisms of these associations. Also, further trials are needed to confirm the efficacy of HDM AIT in young children with allergic asthma.
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| Link do publikacji | House dust mite sensitization and frequent antibiotic courses may suppress remission of rhinosinusitis and asthma symptoms in young children
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| DOI | 10.1111/all.15085 |
