www.nationalcprassociation.com

Naukowcy z Pracowni Biobank oraz Katedry Antropologii i Biofizyki Molekularnej Uniwersytetu Łódzkiego opublikowali pracę, w której przedstawili wyniki na temat różnorodności mitochondrialnego DNA w populacji polskiej Mitochondrial DNA variability of the Polish population. Celem badań było określenie udziałów poszczególnych linii genetycznych mtDNA w populacji a także zobrazowanie genetycznych powiązań między Polakami. Po raz pierwszy takie badania zostały przeprowadzone na tak licznej populacji. Całkowita liczba osób od których próbki zostały wzięte do badań to 5852 osób.

Praca została opublikowana na łamach European Journal of Human Genetics (35 pkt. MNiSW, IF= 4.349). 

 

 

 

 

Justyna Jarczak 1,2Łukasz Grochowalski 1Błażej Marciniak 1Jakub Lach 1,2Marcin Słomka 1,2Marta Sobalska-Kwapis 1,2Wiesław Lorkiewicz 3Łukasz Pułaski 4,5Dominik Strapagiel 1,

Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, Łódź, Poland

BBMRI.pl Consortium, Wrocław, Poland

Department of Antrophology, Faculty of Biology and Environmental Protection, University of Łódź, Łódź, Poland

Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, Łódź, Poland

Laboratory of Transcriptional Regulation, Institute of Medical Biology PAS, Łódź, Poland

 

 

Abstract

The aim of the present study was to define the mtDNA variability of Polish population and to visualize the genetic relations between Poles. For the first time, the study of Polish population was conducted on such a large number of individuals (5852) representing administrative units of both levels of local administration in Poland (voivodeships and counties). Additionally, clustering was used as a method of population subdivision. Performed genetic analysis, included FST, MDS plot, AMOVA and SAMOVA. Haplogroups were classified and their geographical distribution was visualized using surface interpolation maps. Results of the present study showed that Poles are characterized by the main West Eurasian mtDNA haplogroups. Furthermore, the level of differentiation within the Polish population was quite low but the existing genetic differences could be explained well with geographic distances. This may lead to a conclusion that Poles can be considered as genetically homogenous but with slight differences, highlighted at the regional level. Some patterns of variability were observed and could be explained by the history of demographic processes in Poland such as resettlements and migrations of women or relatively weaker urbanisation and higher rural population retention of some regions.